Research · bio-driven Catalysis

Biohybrids

Why not recruit complex living microorganisms for in vivo fuel and chemical production powered by sunlight?

Living cells

Microbial catalysis

Solar chemicals

← All research themes


Our approach

Biology meets materials

Semi-biological photosynthesis combines synthetic light absorbers with live cells to allow for the stable production of complex chemicals. Microbes have metabolic pathways, either natural or engineered, that can be exploited for the synthesis of fuels, platform and fine chemicals or pharmaceuticals. We are interested in interfacing such microbes with custom-made high surface area photoelectrodes or semiconductor particles to study their fundamental biology and drive interesting endergonic reactions. We thereby examine and optimise the material-microbe interface using a range of techniques to ultimately use and manipulate the metabolic pathways of microbes for the solar-driven production of chemicals.

Selected work

Recent publications

A selection of studies on living photocatalysts, microbe–material interfaces and solar-driven chemical synthesis.

Toward Solar-Powered Growth of Autotrophic Escherichia coli Using Photoelectrochemistry

Su, L.; Yeung, C. W. S.; Milshtein, E.; Low, B. Q. L.; Liu, Y.; Milo, R.; Reisner, E. J. Am. Chem. Soc., 2026, 148, 21198–21203.

Designing Microbe–Semiconductor Interfaces for Semibiological Photosynthesis

Song, W.; Quek, G.; Short, M. I. M.; Li, W.; Reisner, E.; Liu, B. Chem. Rev., 2026, 126, 4656–4705.

Organic Semiconducting Hydrogel with Integrated Microbes and Enzymes for Selective Solar CO2 Conversion

Quek, G.; Low, B. Q. L.; Anderlini, S.; Chua, X. W.; Short, M. I. M.; Kim, D.; Stranks, S. D.; Reisner, E. J. Am. Chem. Soc., 2026, 148, 16019–16031.

Adapting gas fermenting bacteria for light-driven domino valorization of CO2

Su, L.; Rodríguez-Jiménez, S.; Short, M. I. M.; Reisner, E. Chem. Sci., 2025, 16, 11801-11808.

Solar-Driven Methanogenesis through Microbial Ecosystem Engineering on Carbon Nitride

Kalathil, S.; Rahaman, M.; Lam, E.; Augustin, T. L.; Greer, H. F.; Reisner, E. Angew. Chem. Int. Ed., 2024, 63, e202409192.

Bacteria–photocatalyst sheet for sustainable carbon dioxide utilization

Wang, Q.; Kalathil, S.; Pornrungroj, C.; Sahm, C. D.; Reisner, E. Nat. Catal., 2022, 5, 633-641.

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